{"id":2014,"date":"2011-03-02T10:25:45","date_gmt":"2011-03-02T15:25:45","guid":{"rendered":"http:\/\/jianmingli.com\/wp\/?p=2014"},"modified":"2011-03-03T08:21:54","modified_gmt":"2011-03-03T13:21:54","slug":"glucosamine-and-chondroitin","status":"publish","type":"post","link":"https:\/\/jianmingli.com\/wp\/?p=2014","title":{"rendered":"Use of Glucosamine and Chondroitin to Treat Osteoarthritis of Knee"},"content":{"rendered":"

It seems<\/h2><\/span>\n

* No observable benefits
\n* No observable side effects
\n* Chondroitin alone is useless
\n* Take glucosamine\/chondroitin combo if you must<\/p>\n

Biochemistry<\/h2><\/span>\n

* Glucosamine promotes production of cartilage building proteins
\n* Chondroitin inhibits production of cartilage destroying enzymes<\/p>\n

Clinical Trials<\/h2><\/span>\n

Glucosamine\/chondroitin Arthritis Intervention Trial (GAIT)<\/h3><\/span>\n

* Publication:
\n– Abstract<\/a>
\n– Full article<\/a>
\n– Follow up abstract<\/a>
\n* Trial facts:
\n– Conducted: 2006
\n– Duration: 24 weeks
\n– Size: 1583 patients
\n* Trial Groups:
\n– Glucosamine group: 3 times daily of 500 mg Glucosamine Hydro Chloride
\n– Chondroitin group: 3 times daily of 400 mg Chondroitin Sulfate
\n– Combo group
\n– Placebo group
\n* Findings
\nPros
\n– May be slightly beneficial for patients with moderate to severe pains
\n– No observable side effects
\nCons
\n– No benefits for all patients combined as a group
\n– No observable structural improvements after two years<\/p>\n

Meta Analysis of Chondroitin Trails<\/h3><\/span>\n

* Publication
\n– Meta-analysis: chondroitin for osteoarthritis of the knee or hip<\/a>
\n* Conclusion
\n– Symptomatic benefit of chondroitin is minimal or nonexistent.
\n– Use of chondroitin in routine clinical practice should therefore be discouraged.<\/p>\n

References<\/h2><\/span>\n

* Glucosamine and Chondroitin for Arthritis: Benefit is Unlikely<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

It seems * No observable benefits * No observable side effects * Chondroitin alone is useless * Take glucosamine\/chondroitin combo if you must Biochemistry * Glucosamine promotes production of cartilage building proteins * Chondroitin inhibits production of cartilage destroying enzymes … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[52],"tags":[],"class_list":["post-2014","post","type-post","status-publish","format-standard","hentry","category-health"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p8cRUO-wu","_links":{"self":[{"href":"https:\/\/jianmingli.com\/wp\/index.php?rest_route=\/wp\/v2\/posts\/2014","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jianmingli.com\/wp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jianmingli.com\/wp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jianmingli.com\/wp\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/jianmingli.com\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2014"}],"version-history":[{"count":5,"href":"https:\/\/jianmingli.com\/wp\/index.php?rest_route=\/wp\/v2\/posts\/2014\/revisions"}],"predecessor-version":[{"id":2016,"href":"https:\/\/jianmingli.com\/wp\/index.php?rest_route=\/wp\/v2\/posts\/2014\/revisions\/2016"}],"wp:attachment":[{"href":"https:\/\/jianmingli.com\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2014"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jianmingli.com\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2014"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jianmingli.com\/wp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2014"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}